According to the PCB, the 38-year-old is suffering a niggle and he will be rested during the first T20I, which is to be played on February 2, to help him gain fitness for the next two 20-over games.
INJURY UPDATE: Mohammad Hafeez has a slight hamstring niggle and will be rested from tonight’s first T20I that will give him every chance of being fit for the next two #SAvPAK games.
— PCB Official (@TheRealPCB) February 1, 2019
Pakistan will also be playing without their captain, Sarfraz Ahmed, who has been suspended for four games due to a breach of Anti-Racism Code.
In absence of Sarfraz, Shoaib Malik will lead the side, who also captained the team in the last two ODIs of the series.
Pakistan have lost the three-match Test series by 3-0 and suffered a defeat in five-match ODI series by 3-2.
However, T20 is the favourite format of Pakistan, they are the top-ranked side of the world and also possess Babar Azam and Shadab Khan in the ranks, who are the 1st and 2nd-ranked batsman and bowler in the format respectively.